Born in Hanover in 1904, Brill studied commercial graphics at the Kunstgewerbeschule in Berlin and attended Johannes Itten’s school, where he developed an interest in photography. After working as a graphic designer in Herbert Bayer’s studio, in 1932 he established an atelier for advertising design with Hedwig Bornemann. Following the Second World War, he settled in Hofgeismar, where he resumed his photographic work and exhibited his first post-war photographs in Kassel in 1949. He developed his method of Photoanalyse, using photographs taken separately and combined to produce new, highly detailed images for artistic, scientific and industrial purposes. In the early 1950s he began working in this field professionally, and in 1970 he established the Institut für Photoanalyse in Hofgeismar-Carlsdorf. Brill also produced documentary films and continued to work in industrial and advertising photography.