After studying at the Accademia di Belle Arti in Rome, Prampolini came into contact with artists and intellectuals from across the European avant-garde, from Picasso and Jean Cocteau to Mondrian and Kandinsky. One of the leading figures of Italian Futurism, he nevertheless maintained close connections with other movements, including Dada, Section d’Or, Cercle et Carré, Abstraction-Création, the Bauhaus and De Stijl, working simultaneously as an artist and architect. He contributed to the magazine Varietas and later founded Noi. Still very young, he designed the sets for the Futurist films Thaïs and Perfido incanto. He went on to establish the Casa d’Arte Italiana and the Teatro della Pantomima Futurista, continuing to work in stage design, while also contributing to international exhibitions in San Francisco and New York, where he created decorative panels for several rooms. Throughout this period, he devoted himself increasingly to the exploration of polimaterismo.