After irregular music studies, Cangiullo started his career as a songwriter, playing in the ever popular Caffè Concerto. In 1910 he met Marinetti, who introduced him to Futurism. From 1913 he started to collaborate with Lacerba magazine, as well as producing paintings and sculptures. Soon after Piedigrotta, he published Verde Nuovo, Caffè-Concerto: alfabeto a sorpresa, and Il mobilio futurista. He was also Creative Director of the Compagnia del Teatro della Sorpresa, collaborating with Depero and Prampolini. In 1923 he created Poesia Pentagrammata, in which poems are written directly on music sheets. From 1924 he moved away from Futurism and published the collection of poems Serate futuriste.